The ULTIMATE Product For Men

Testerol-o is for YOU if you want :

  • A drastic libido boost
  • Increased muscle strength and quicker recovery after workouts
  • A better more restful sleep
  • A sense of calm and well being throughout the day
  • Help in weight loss and toning/buffing the body


GAMMA ORYZANOL- The amazing nutrient!

by Ronald L. Myers, CNC

Imagine a single nutrient that possesses the following properties: anti-oxidant, anti-carcinogenic, anti-ulcer, anti-stress, lipotrophic effects, hypothalamic effects, endocrinological effects, athletic benefits and benefits to the skin similar to Vitamin E. The nutrient with such wide-ranging power is Gamma Oryzanol. In this issue I will cover this nutrient in detail; what is it, where does it come from and HOW does it work.

It is a nutrient with a strange sounding name that occurs naturally in many plants, especially the rice plant. The scientific name for rice is Oryza sativa, from which gamma oryzanol gets its name.

The chemical structure is that of two molecules in one, first a plant sterol and second ferulic acid. The sterol (triterpenyl alcohol) is the largest part of the molecule. Hormones such as testosterone, estrogen, progesterone, DHEA and corticosteroids, etc. are derived from cholesterol and can be thought of as modified sterols1. For this reason you may consider Gamma Oryzanol as a universal hormone precursor.

Ferulic acid is one of the hydroxycinnamic acids, a subgroup of plant phenolic acids2. In its purified state, it tastes and smells like cinnamon. Ferulic acid is a precursor for lignin, the polymer that makes up most physical support structures of plants. In rice, ferulic acid is added on to sterols, forming gamma oryzanol. In other plants it is bound to sugars, cell walls, cellulose, etc., as well as being found in its free form3

There is no conclusive evidence of the presence of gamma oryzanol in any other plant than rice. This does not mean rice is the only source of gamma oryzanol in nature; methods of plant analysis for compounds similar to gamma oryzanol usually include hydrolysis, which could easily destroy it leaving sterols and ferulic acid as end products. Since rice is a plentiful and economic source of the nutrient there is not much incentive to do a systematic search for alternative sources.

Records indicate the Japanese were the first to isolate gamma oryzanol from rice in 1943. Today, rice is still the only known source of the nutrient.
1 Hahlbrock, K., Grisebach, H., Enzymatic controls in the biosynthesis of lignin and flavonoids, Ann. Rev. Plant Physiol., 30,105, 1979. 2 Ibid.
3 Winter, M. and Herrmann, K., Esters and glucosides of hydroxycinnamic acids in vegetables, J. Agric. Food Chem., 34, 616, 1986.
eBytes Issue 35Ronald L. Myers, CNC Copyright © 2004 All Rights Reserved


Testerol-O, an ester of ferulic acid, is a natural antioxidant that is primarily found in grain products. Produced from rice bran oil, Testerol-Olhas been traditionally used by the Japanese as a medicinal agent in the treatment of menopause, gastrointestinal problems, and elevated cholesterol/triglyceride levels. Due to its potent antioxidant effects, Testerol-O may also be effective at inhibiting certain cancers, as well as limiting the damaging effects of radiation exposure and chemotherapy. [1, 2]
Research suggests that gamma oryzanol the compound found in Testerol-O acts on the hypothalamus and pituitary glands, inhibiting the output of certain hypothalamic and pituitary hormones. Hormones affected include; growth hormone, thyroid-stimulating hormone (TSH), prolactin, and leutinizing hormone. However, studies remain mixed on gamma oryzanol’s mechanism of action; with some studies actually reporting an increase in the secretion percentages of the aformentioned hormone. More studies are needed to fully determine the overall effects of gamma oryzanol on hypothalamic and pituitary hormones. [1, 2]


TESTEROL-O may be useful for the treatment of high serum cholesterol and triglyceride levels. [1, 6] One study found that treatment with gamma oryzanol reduced cholesterol levels in mildly hypercholesterolemic men in a 4-week period. [3] Several studies suggest that gamma oryzanol’s cholesterol-lowering effects may be due to its ability to increase conversion of cholesterol to bile acid, increase excretion of bile acid, and reduce absorption of cholesterol. [1, 7, 8]

TESTEROL-O may have anticancerous properties, Several preliminary animal studies have shown that gamma oryzanol may help inhibit tumor cell growth. [9, 10] One study suggests that gamma oryzanol may protect against the damaging effects of radiation exposure and chemotherapy.[11] More human studies are needed to determine gamma oryzanol’s anticancer effects.

TESTEROL-O may be useful for treatment of menopausal symptoms. Several studies found that treatment with gamma oryzanol improved symptoms in menopausal women.[1, 2, 12, 13] TESTEROL-Os beneficial effects appear to be due to its ability to reduce secretion of leutinizing hormone (LH) by the pituitary and increase excretion of endorphins by the hypothalamus. [1]

TESTEROL-O may be useful for athletes and body builders to increase lean body mass and strength, improve recovery after workouts, and help repair the muscle damage that can result from intense exercise. [1, 14] A particular double-blind study reports that bodybuilders who took 30 milligrams daily of gamma oryzanol increased body weight and strength over a period of 8-weeks.

TESTEROL-O may be useful for various digestive disorders such as stomach ulcers, gastritis, and irritable bowel syndrome. [1, 17, 18] TESTEROL-O beneficial effects appear to be due to its ability to reduce the secretion of gastric acid and normalize the nervous system control of digestive secretions.

Dosage: 300 - 500 milligrams daily for therapeutic applications.
Delivery Forms: Tablets, capsules, and liquid. [1, 2]
Gamma Oryzanol Deficiencies and Toxicities
Gamma Oryzanol Deficiencies
Deficiency signs and symptoms have not been reported in medical literature. [1]
GammaOrazanol Toxicities
Pregnant, lactating women, and children should not take supplemental gamma oryzanol, unless recommended by a health care provider. [1, 2]
TESTEROL-O is considered a safe, natural substance. No side effects have been reported with its use.
1. Murray MT. Encyclopedia of Nutritional Supplements, NY: Three Rivers Press, 1996: 332-335.
2. Gamma Oryzanol, Dietary Supplement Information Bureau:http://content.nhiondemand.com/dse/consumer/monoAll-style.asp?objID=100401&ctype=ds&mtyp=4
3. Berger A, Rein D, Schafer A, et al. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men. Eur J Nutr. May2004;:1-11.
4. Scavariello EM, Arellano DB. Gamma-oryzanol: an important component in rice bran oil. Arch Latinoam Nutr. Mar1998;48(1):7-12.
5. Nakayama S, Manabe A, Suzuki J, et al. Comparative effects of two forms of gamma-oryzanol in different sterol compositions on hyperlipidemia induced by cholesterol diet in rats. Jpn J Pharmacol. Jun1987;44(2):135-43.
6. Sasaki J et al. Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin Ther 1990;12:263-268.
7. Sakamoto K, Tabata T, Shirasaki K. Effects of gamma-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats. Jpn J Pharmacol. Dec1987;45(4):559-65.
8. Seetharamaiah GS, Chandrasekhara N. Effect of oryzanol on cholesterol absorption & biliary & fecal bile acids in rats. Indian J Med Res. Dec1990;92:471-5.
9. Tanaka T et al. Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenisis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis 1993; 14:1321-1325.
10. Asanoma M et al. Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two stage tumorigenesis. Carcinogenesis 1994; 15:2069-2071.
11. Graf E. Antioxidant potential of ferulic acid. Free Rad Biol Med 1992; 13:435-448.
12. Ishihara M. Effect of of gamma-oryzanol on serum lipid peroxide levels and climacteric disturbances. Asia Oceania J Ostet Gynecol 1984; 10:317
13. Ishihara M, Ito Y, Nakakita T, et al. Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides. Nippon Sanka Fujinka Gakkai Zasshi. Feb1982;34(2):243-51.
14. Bucci LR, et al. Effect of ferulate on strength and body composition of weightlifters. J Appl Sport Sci Res. 1990;4:104-109.
15. Fry AC, Bonner E, Lewis DL, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr. Dec1997;7(4):318-29.
16. Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr. Jun1991;1(2):170-7.
17. Ichimaru Y, Moriyama M, Ichimaru M, Gomita Y. Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice. Nippon Yakurigaku Zasshi. Dec1984;84(6):537-42.
18. Mizuta K, Itaya K. Effects of gamma-oryzanol on gastric secretions in rats. Nippon Yakurigaku Zasshi. Mar1978;74(2):285-95.

Research conducted by: Fl Nutri Chem Technology. 12/12

greater gains in muscle size and strength